A histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine; competes with [3H]diltiazem for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM); decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM); decreases negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48%

Carbinoxamine (maleate) – 5 g

Brand:
Cayman
CAS:
3505-38-2
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Carbinoxamine is a competitive histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine.{23220} It also competes with [3H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM).{41288} Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.  

 

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Description

A histamine H1 receptor antagonist (Ki = 2.3 nM) and first generation antihistamine; competes with [3H]diltiazem for binding to the benzothiazepine site on rat cardiomyocytes (Ki = 1.08 nM); decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC50 = 250 nM); decreases negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48%

Formal name: 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-ethanamine, (2Z)-2-butenedioate

Synonyms:  NSC 62362

Molecular weight: 406.9

CAS: 3505-38-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Immunology & Inflammation|Allergy

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