A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo

Carbidopa (hydrate) – 50 mg

Brand:
Cayman
CAS:
38821-49-7
Storage:
-20
UN-No:
Non-Hazardous - /

Carbidopa is a peripherally-restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.{41269} Carbidopa (100 mg/kg) pretreatment in dog increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.{41270} Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons.{41271} It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.  

 

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SKU: 23783 - 50 mg Category:

Description

A dopamine decarboxylase inhibitor; inhibits conversion of L-DOPA to dopamine in the periphery; increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66% in dog when administered at a dose of 100 mg/kg; potentiates the activity of AhR; inhibits proliferation of pancreatic cancer cells in vitro and tumor growth in vivo

Formal name: (αS)-α-hydrazinyl-3,4-dihydroxy-α-methyl-benzenepropanoic acid, monohydrate

Synonyms: 

Molecular weight: 244.2

CAS: 38821-49-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Activators||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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