A derivative of β-glycyrrhetinic acid a major metabolite of glycyrrhizin

Carbenoxolone (sodium salt) – 1 g

Brand:
Cayman
CAS:
7421-40-1
Storage:
-20
UN-No:
Non-Hazardous - /

Carbenoxolone is a derivative of β-glycyrrhetinic acid (Item No. 11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to β-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties.{29513} Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Item No. 10007815) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension.{11854} It is also reported to inhibit 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.{24097}  

 

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Description

A derivative of β-glycyrrhetinic acid a major metabolite of glycyrrhizin, one of the main constituents of licorice, with anti-ulcerative and anti-inflammatory properties; inhibits 11β-HSD1 conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension; also inhibits 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects

Formal name: (3β,20β)-3-(3-carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid, disodium salt

Synonyms: 

Molecular weight: 614.7

CAS: 7421-40-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Neuroscience

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