An inhibitor of PDE2 and PDE3; inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM); induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria

Carbazeran – 5 mg

Brand:
Cayman
CAS:
70724-25-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3.{47008} It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM).{47009} It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively. Carbazeran is also a substrate for the enzyme aldehyde oxidase (AOX1), which is involved in the metabolism of xenobiotics.{47010,47011}  

 

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SKU: 26092 - 5 mg Category:

Description

An inhibitor of PDE2 and PDE3; inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM); induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively; a substrate for AOX1

Formal name: N-ethyl-carbamic acid, 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl ester

Synonyms: 

Molecular weight: 360.4

CAS: 70724-25-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Toxicology|Drug Metabolism

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