A carbamate insecticide; inhibits AChE (IC50 = 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells; Ki. = 5.7 nM for rat brain AChE); decreases the weight of lymphoid organs and serum levels of IL-2

Carbaryl – 100 mg

Brand:
Cayman
CAS:
63-25-2
Storage:
-20
UN-No:
Non-Hazardous - /

Carbaryl is a carbamate insecticide that inhibits acetylcholinesterase (AChE; IC50 = 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells; Ki = 5.7 µM for rat brain AChE).{39792,39793} Carbaryl administered at a dose of 30 mg/kg for 28 days in rats decreases the weight of spleen and thymus, proliferation of lymphocytes, and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, and increases the serum levels of IL-4 and IL-10.{39794} It increases CaMKII, GAP-43, and tau protein levels in the hippocampus and tau levels in the cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten, whereas tau protein levels are decreased four months after administration with no change in CaMKII or GAP-43 compared with control mice. These effects occur at non-toxic doses where acetylcholinesterase is inhibited only during the first six hours following treatment. Formulations containing carbaryl have been used to control insects in agriculture.  

 

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Description

A carbamate insecticide; inhibits AChE (IC50 = 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells; Ki. = 5.7 nM for rat brain AChE); decreases the weight of lymphoid organs and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, while increasing serum levels of IL-4 and IL-10; increases CaMKII, GAP-43, and tau levels in the hippocampus and cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten

Formal name: 1-(N-methylcarbamate)1-naphthalenol

Synonyms:  Arylam|Dyna-carbyl|ENT 23969|NSC-27311|UC-7744|α-Naphthalenyl methyl Carbamate|α-Naphthyl methyl Carbamate

Molecular weight: 201.2

CAS: 63-25-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience||Research Area|Toxicology|Environmental|Agriculture

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