A competitive antagonist of TRPV1 which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia (IC50 = 0.42 µM) and Chinese hamster ovary cells (IC50 = 17 nM); does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1

Capsazepine – 10 mg

Brand:
Cayman
CAS:
138977-28-3
Storage:
-20
UN-No:
Non-Hazardous - /

Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}  

 

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SKU: 10007518 - 10 mg Category:

Description

A competitive antagonist of TRPV1 which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia (IC50 = 0.42 µM) and Chinese hamster ovary cells (IC50 = 17 nM); does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1

Formal name: N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

Synonyms: 

Molecular weight: 376.9

CAS: 138977-28-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Pain Research

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