A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production

Capsaicin – 100 mg

Brand:
Cayman
CAS:
404-86-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.{55276,55277,55278,55279} It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619.{55276} Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages.{55277} Capsaicin induces substance P release in rat spinal cord slices with an EC50 value of 2.3 µM.{55278} It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.).{55279} Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.  

 

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Description

A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated mouse peritoneal macrophages at 10 and 50 µM; induces substance P release in rat spinal cord slices (EC50 = 2.3 µM); reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.)

Formal name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide

Synonyms: 

Molecular weight: 305.4

CAS: 404-86-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Pain Research

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