Description
A CAP with antibacterial activity; active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively); increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro; reduces the biomass and number of colony-forming units in E. coli biofilms; inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters; reduces bacterial load in E. coli-infected wounds in mice at 40 mg/kg; cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells (HC50 = 48 μM)
Formal name: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-((R)-5-(benzyloxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triyl tris(2-((S)-2-amino-3-methylbutanamido)acetate)
Synonyms:
Molecular weight: 967.3
CAS: 2292123-03-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia
