A cannabidiol derivative that potently and selectively inhibits 15-LO (IC50 =0.28 µM); does not inhibit 5-LO effectively (IC50 >200 µM)

Cannabidiol dimethyl ether – 1 mg

Brand:
Cayman
CAS:
1242-67-7
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.{346} The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.{1462} CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.{17111} It does not inhibit 5-LO effectively (IC50 >200 µM).{17111}  

 

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Description

A cannabidiol derivative that potently and selectively inhibits 15-LO (IC50 =0.28 µM); does not inhibit 5-LO effectively (IC50 >200 µM)

Formal name: 1,3-dimethoxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-benzene

Synonyms:  Cannabidiol-2′,6′-dimethyl ether|CBDD

Molecular weight: 342.5

CAS: 1242-67-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience|Cannabinoid Research

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