An internal standard for the quantification of canagliflozin by GC- or LC-MS

Canagliflozin-d4 – 1 mg

Brand:
Cayman
CAS:
1997338-61-0
Storage:
-20
UN-No:
Non-Hazardous - /

Canagliflozin-d4 is intended for use as an internal standard for the quantification of canagliflozin (Item No. 11575) by GC- or LC-MS. Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, have been used to treat type 2 diabetes mellitus.{33509}  

 

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SKU: 25223 - 1 mg Category:

Description

An internal standard for the quantification of canagliflozin by GC- or LC-MS,

Formal name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl-2,3,5,6-d4)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol

Synonyms: 

Molecular weight: 448.5

CAS: 1997338-61-0

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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