An inhibitor of SGLT2 (IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM); lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals

Canagliflozin – 5 mg

Brand:
Cayman
CAS:
842133-18-0
Storage:
-20
UN-No:
Non-Hazardous - /

Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).{18745} Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.{18745,33510} Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.{33509}  

 

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SKU: 11575 - 5 mg Category:

Description

An inhibitor of SGLT2 (IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM); lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals

Formal name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol

Synonyms:  JNJ-24831754|TA-7284

Molecular weight: 444.5

CAS: 842133-18-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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