An isoflavone glycoside; scavenges 34.5% of generated DPPH radicals compared to a vehicle control in a cell-free assay at 100 μg/ml; inhibits LPS-induced cytotoxicity

Calycosin 7-O-β-D-Glucoside – 25 mg

Brand:
Cayman
CAS:
20633-67-4
Storage:
-20
UN-No:
Non-Hazardous - /

Calycosin 7-O-β-D-glucoside is an isoflavone glycoside that has been isolated from A. mongholicus and A. membranaceus and has antioxidant, anti-inflammatory, and neuroprotective biological activities.{43143,43144,43145} It scavenges 34.5% of generated 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals compared to a vehicle control when used at a concentration of 100 μg/ml in a cell-free assay.{43143} Calycosin 7-O-β-D-glucoside (10 μg/ml) inhibits cytotoxicity, intracellular reactive oxygen species (ROS) production, and cytoskeletal defects induced by LPS in human umbilical vein endothelial cells (HUVECs).{43144} In vivo, calycosin 7-O-β-D-glucoside (26.8 mg/kg) reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{43145}  

 

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SKU: 25095 - 25 mg Category:

Description

An isoflavone glycoside; scavenges 34.5% of generated DPPH radicals compared to a vehicle control in a cell-free assay at 100 μg/ml; inhibits LPS-induced cytotoxicity, ROS production, and cytoskeletal defects in HUVECs at 10 μg/ml; reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 26.8 mg/kg

Formal name: 7-(β-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 446.4

CAS: 20633-67-4

Purity: ≥98%

Formulation: A lyophilisate

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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