An isoflavone with diverse biological activities; ER partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM

Calycosin – 25 mg

Brand:
Cayman
CAS:
20575-57-9
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Calycosin is an isoflavone and phytoestrogen with diverse biological activities.{41872,41873,41874,43143,41875,41876} It is an estrogen receptor (ER) partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively).{41872} Calycosin induces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay and angiogenesis in zebrafish via activation of ERs and ERK1/2. It has antiplasmodial and antiprotozoal activities, reducing the growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively) and exhibiting selective toxicity for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively).{41873,41874} Calycosin scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) free radicals in a cell-free assay and inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml).{43143} In vivo, calycosin (12.5 and 25 mg/kg) reduces alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).{41875} It also decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{41876}  

 

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Description

An isoflavone with diverse biological activities; ER partial agonist that inhibits 17β-estradiol binding to ERα and ERβ (IC50s = 83.14 and 40.38 μM, respectively); induces tube formation by HUVECs in a Matrigel™ assay and angiogenesis in zebrafish; reduces growth of the poW and Dd2 strains of P. falciparum (IC50s = 4.2 and 9.8 μg/ml, respectively); selectively toxic for T. brucei brucei over Vero cells (IC50s = 12.7 and 159 μM, respectively); scavenges DPPH free radicals in a cell-free assay; inhibits xanthine/xanthine oxidase-induced toxicity in PC12 cells (EC50 = 50 ng/ml); reduces ALT and AST activity, triglyceride accumulation, and hepatic fibrosis in a mouse model of NASH at 12.5 and 25 mg/kg; decreases infarct volume and brain edema in a rat model of focal cerebral ischemia and reperfusion injury

Formal name: 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 284.3

CAS: 20575-57-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Phytosterols||Product Type|Biochemicals|Ox Stress Reagents||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Xanthine Oxidase

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