Description
Calponin-1 is an actin binding protein and a component of smooth muscle cell (SMC) contractile machinery that is encoded by CNN1 in humans.{54434,54435} It is a thin filament-associated protein expressed exclusively in SMCs that interacts with actin to inhibit the movement of actin and myosin, as well as the actin-activated MgATPase activity of phosphorylated myosin.{54436} High levels and low levels of calponin-1 are associated with low and high disease progression risk, respectively, in patients with ductal carcinoma in situ (DCIS).{54437} Downregulation of arterial Cnn1 expression promotes proliferation of vascular SMCs (VSMCs) in a DOCA-salt rat model of hypertension and a pig model of hypertension induced by aortic coarctation.{54435} Cayman’s Calponin-1 (C-Term) Rabbit Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications.
Synonyms: CaP
Immunogen: Peptide from the C-terminal region of human calponin-1
Formulation: 100 µl of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ICC, WB
Origin:
Stability: 365 days
Application|Immunocytochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cytoskeleton & Motor Proteins
