A cell permeable

Calpain Inhibitor III – 10 mg

Brand:
Cayman
CAS:
88191-84-8
Storage:
-20
UN-No:
Non-Hazardous - /

The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates.{13816} Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2).{22713} Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia.{22714} Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.{22712}  

 

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Description

A cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2); crosses the blood-brain barrier to inhibit brain cysteine protease activity; reported to have protective effects in numerous rodent models of neurotrauma and cardiac ischemia

Formal name: N-[(1S)-1-[[(1-formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]-carbamic acid, phenylmethyl ester

Synonyms:  MDL 28170

Molecular weight: 382.5

CAS: 88191-84-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Neuroscience|Neuroprotection|Ischemia

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