Description
A peptide hormone that lowers blood calcium level and inhibits bone resorption; binds to hCTR2 with IC50 values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively; induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC50 = 0.166 nM); inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID50 = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED15 = 33.9 mg/kg)
Formal name: L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-Lthreonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide, cyclic (1→7)-disulfide, trifluoroacetate salt
Synonyms: Calcitonin (1-32) (salmon)|Salcatonin|sCT|Thyrocalcitonin (salmon)
Molecular weight: 3,431.90
CAS: 171052-37-2
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors
