A low-calcemic vitamin D receptor agonist; increases keratinocyte differentiation and reduces expression of transcriptional activators in the inflammatory response; induces T-cell differentiation in keratinocytes

Calcipotriol (hydrate) – 10 mg

Brand:
Cayman
CAS:
147657-22-5
Storage:
-20
UN-No:
Non-Hazardous - /

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3).{15198} Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response.{15197} Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.{15196}  

 

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SKU: 10009599 - 10 mg Category:

Description

A low-calcemic vitamin D receptor agonist; increases keratinocyte differentiation and reduces expression of transcriptional activators in the inflammatory response; induces T-cell differentiation in keratinocytes

Formal name: 24-cyclopropyl-(1α,3β,5Z,7E,22E,24S)-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol, monohydrate

Synonyms:  Calcipotriene

Molecular weight: 430.6

CAS: 147657-22-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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