A CAIX inhibitor (Ki = 0.007 µM for the recombinant human enzyme); selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6

CAIX Inhibitor S4 – 50 mg

Brand:
Cayman
CAS:
1330061-67-0
Storage:
-20
UN-No:
Non-Hazardous - /

CAIX inhibitor S4 is an inhibitor of carbonic anhydrase IX (CAIX; Ki = 0.007 µM for the recombinant human enzyme).{54261} It is selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6, 0.55, and 0.002 µM, respectively). CAIX inhibitor S4 inhibits proliferation of HT-29 and MDA-MB-231, but not HCT116, cancer cells under anoxic conditions (IC50s = 20, 481, and >1,000 µM, respectively). CAIX inhibitor S4 (10 mg/kg, i.p.) reduces the number of lung metastases, but not primary tumor growth, in an MDA-MB-231 mouse xenograft model.  

 

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SKU: 31119 - 50 mg Category:

Description

A CAIX inhibitor (Ki = 0.007 µM for the recombinant human enzyme); selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6, 0.55, and 0.002 µM, respectively); inhibits proliferation of HT-29 and MDA-MB-231, but not HCT116, cancer cells under anoxic conditions (IC50s = 20, 481, and >1,000 µM, respectively); reduces the number of lung metastases, but not primary tumor growth, in an MDA-MB-231 mouse xenograft model at 10 mg/kg

Formal name: sulfamic acid, 4-[[[(3,5-dimethylphenyl)amino]carbonyl]amino]phenyl ester

Synonyms: 

Molecular weight: 335.4

CAS: 1330061-67-0

Purity: ≥98%

Formulation: A solid

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