A non-selective inhibitor of CaCCs; blocks ATP-stimulated chloride conductance in human salivary gland

CaCC(inh)-A01 – 10 mg

Brand:
Cayman
CAS:
407587-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

CaCC(inh)-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 µM).{37016} CaCC(inh)-A01 (30 µM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride.{34635} CaCC(inh)-A01 also attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines through targeted degradation of the protein and reduces BKCa channel activity in human red blood cells.{37017},{37018}  

 

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Description

A non-selective inhibitor of CaCCs; blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelial cells (mean IC50 = 10 µM); induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride; attenuates CaCC TMEM16-A-induced proliferation in cancer cell lines; reduces BKCa channel activity in human red blood cells

Formal name: 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Synonyms:  TMEM16 Blocker I

Molecular weight: 347.4

CAS: 407587-33-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Vasculature|Vasodilation

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