An HIV-1 integrase inhibitor (IC50 = 3 nM in a strand transfer assay); inhibits HIV replication in MT-4 cells and PBMCs (IC50s = 1.3 and 0.2 nM

Cabotegravir – 25 mg

Brand:
Cayman
CAS:
1051375-10-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Cabotegravir is an inhibitor of HIV-1 integrase (IC50 = 3 nM in a strand transfer assay).{45297} It inhibits HIV replication in MT-4 cells and peripheral blood mononuclear cells (PBMCs; IC50s = 1.3 and 0.2 nM, respectively). Cabotegravir (50 mg/kg) is protective against simian/human immunodeficiency virus (SHIV) infection in macaques when administered 1 week prior to viral challenge.{45298}  

 

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SKU: 27215 - 25 mg Category:

Description

An HIV-1 integrase inhibitor (IC50 = 3 nM in a strand transfer assay); inhibits HIV replication in MT-4 cells and PBMCs (IC50s = 1.3 and 0.2 nM, respectively); protective against SHIV infection in macaques at 50 mg/kg

Formal name: (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Synonyms:  GSK1265744A|GSK744

Molecular weight: 405.4

CAS: 1051375-10-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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