A cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells; used to study the role of cathepsin B in neurodegeneration

CA-074 methyl ester – 1 mg

Brand:
Cayman
CAS:
147859-80-1
Storage:
-20
UN-No:
Non-Hazardous - /

CA-074 methyl ester is a cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells.{29705,29706} The methyl ester is hydrolyzed by intracellular esterases releasing the active inhibitor, CA-074. This compound has primarily been used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis.{29704,29707,29703,29708}  

 

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Description

A cell-permeable inhibitor of cathepsin B and L in vivo and in whole cells; used to study the role of cathepsin B in neurodegeneration, cancer cell metastasis, necrosis, and rheumatoid arthritis

Formal name: N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline, methyl ester

Synonyms: 

Molecular weight: 397.5

CAS: 147859-80-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Neuroscience

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