A selective cathepsin B inhibitor (Kis = 0.0087

CA-074 – 1 mg

Brand:
Cayman
CAS:
134448-10-5
Storage:
-20
UN-No:
Non-Hazardous - /

CA-074 is a selective epoxysuccinyl peptide inhibitor of the cysteine protease cathepsin B (Kis = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively).{14250} It inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast cancer cells in a concentration-dependent manner and reduces the number of lung and bone metastasis in a 4T1.2 mouse xenograft model, without affecting primary tumor growth, when administered at a dose of 50 mg/kg.{41935} CA-074 (0.1 and 0.2 mg/animal per day) reduces mercury-induced increases in expression of TNF-α, IL-1β, and the inflammasome component NRLP3 and decreases the severity of mercury-induced skin induration in mice.{41937} CA-074 also reduces ischemia-induced hippocampal neuron cell death in monkeys.{41936}  

 

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SKU: 24679 - 1 mg Category:

Description

A selective cathepsin B inhibitor (Kis = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively); inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast cancer cells; reduces the number of lung and bone metastasis in a 4T1.2 mouse xenograft model at 50 mg/kg; reduces mercury-induced increases in expression of TNF-α, IL-1β, and the inflammasome component NRLP3 and decreases the severity of mercury-induced skin induration in mice at 0.1 and 0.2 mg/kg; reduces ischemia-induced hippocampal neuron cell death in monkeys

Formal name: N-[[3S-[(propylamino)carbonyl]-2S-oxiranyl]carbonyl]-L-isoleucyl-L-proline

Synonyms: 

Molecular weight: 383.4

CAS: 134448-10-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neuroprotection|Ischemia

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