A cell-permeable analog of naturally occurring ceramides; cytotoxic to U937 cells (IC50 = 17 μM); induces nuclear DNA fragmentation; a substrate for E. coli diacylglycerol kinase; activates CAPK; enhances V. cholerae cytolysin pore formation in liposome lipid membranes (RD50 = ~5 μg/ml)

C8 D-threo Ceramide (d18:1/8:0) – 1 mg

Brand:
Cayman
CAS:
175892-43-0
Storage:
-20
UN-No:
Non-Hazardous - /

C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{5258} It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide (Item No. 62540).{5258,38647} C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase.{5258} It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.{40652} [Matreya, LLC. Catalog No. 1810]  

 

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SKU: 24391 - 1 mg Category:

Description

A cell-permeable analog of naturally occurring ceramides; cytotoxic to U937 cells (IC50 = 17 μM); induces nuclear DNA fragmentation; a substrate for E. coli diacylglycerol kinase; activates CAPK; enhances V. cholerae cytolysin pore formation in liposome lipid membranes (RD50 = ~5 μg/ml)

Formal name: N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide

Synonyms:  D-threo Cer(d18:1/8:0)|D-threo Ceramide (d18:1/8:0)|N-octanoyl-D-threo-Sphingosine

Molecular weight: 425.7

CAS: 175892-43-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Lipids|Sphingolipids||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Lipid Biochemistry|Sphingolipids

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