An inhibitor of the HAT p300 (IC50 = 1.6 μM); competitively binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases; blocks the growth of human melanoma

C646 – 5 mg

Brand:
Cayman
CAS:
328968-36-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 μM).{18217} It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases.{18217} The action of C646 appears to be irreversible through covalent modification of the enzyme target.{18217} It blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro.{18217,22225,22222} C646 has been used to study the role of p300-mediated acetylation in such models as fear extinction memory and the regulation of immediate-early genes.{22223,22224}  

 

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SKU: 10549 - 5 mg Category:

Description

An inhibitor of the HAT p300 (IC50 = 1.6 μM); competitively binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases; blocks the growth of human melanoma, leukemia, lung, and prostate cancer cells in vitro

Formal name: 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyra-zol-1-yl]-benzoic acid

Synonyms: 

Molecular weight: 445.4

CAS: 328968-36-1

Purity: ≥98% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation

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