An inhibitor of neutral ceramidase; It increases total ceramide levels in wild-type MEFs and HT-29 cells but not in MEFs lacking neutral ceramidase; inhibits proliferation of

C6 Urea Ceramide – 1 mg

Brand:
Cayman
CAS:
486991-52-0
Storage:
-20
UN-No:
Non-Hazardous - /

C6 urea ceramide is an inhibitor of neutral ceramidase.{46501} It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 µM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.  

 

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Description

An inhibitor of neutral ceramidase; It increases total ceramide levels in wild-type MEFs and HT-29 cells but not in MEFs lacking neutral ceramidase; inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells at 5 and 10 µM; reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model at 1.25, 2.5, and 5 mg/kg for five days

Formal name: N-hexyl-N’-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-urea

Synonyms:  C6 Ceramide (d18:1/6:0) Urea|Cer(d18:1/6:0) Urea|D-erythro-Urea-C6-Ceramide

Molecular weight: 426.7

CAS: 486991-52-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Lipid Biochemistry|Sphingolipids

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