A fluorescently tagged sphingolipid; biologically active derivative of sphingomyelin; used to study the metabolism and transport of sphingomyelins

C6 NBD Sphingomyelin (d18:1/6:0) – 1 mg

Brand:
Cayman
CAS:
94885-04-8
Storage:
-20
UN-No:
Non-Hazardous - /

C6 NBD sphingomyelin is a biologically active derivative of sphingomyelin (Item Nos. 22674 | 24345) that is tagged with a fluorescent C6 nitrobenzoxadiazole (C6 NBD; Item No. 18871) group. C6 NBD sphingomyelin has been used to study the metabolism and transport of sphingomyelins.{38317,39498} It is degraded in the plasma membrane to C6 NBD ceramide (Item No. 62527) by neutral sphingomyelinase, an enzyme with three-fold higher activity in undifferentiated HT29 cells than in differentiated cells.{38317} Unlike endogenous long-chain sphingomyelin and C6 sphingomyelin, C6 NBD sphingomyelin can be transported to the cell surface even in the presence of the vesicular transport inhibitor brefeldin A (Item No. 11861), but this transport can be blocked by multidrug resistance protein inhibitors in CHO cells.{39498} This product is a mixture of the D-erythro and L-threo isomers of sphingomyelin. [Matreya, LLC. Catalog No. 1912]  

 

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SKU: 24328 - 1 mg Category:

Description

A fluorescently tagged sphingolipid; biologically active derivative of sphingomyelin; used to study the metabolism and transport of sphingomyelins

Formal name: (7S)-4-hydroxy-7-[(1R,2E)-1-hydroxy-2-hexadecen-1-yl]-N,N,N-trimethyl-14-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-9-oxo-3,5-dioxa-8-aza-4-phosphatetradecan-1-aminium, 4-oxide inner salt

Synonyms:  NBD SM(d18:1/6:0)|NBD Sphingomyelin (d18:1/6:0)|N-hexanoyl-NBD Sphingosylphosphorylcholine

Molecular weight: 740.9

CAS: 94885-04-8

Purity: ≥98%

Formulation: A solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Sphingolipids

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