A cell-permeable analog of naturally occurring ceramides; cytotoxic to U937 cells in vitro (IC50 = 18 μM); metabolically inactive; promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM; enhances PMA-induced IL-4 production in EL4 T cells

C6 D-threo Ceramide (d18:1/6:0) – 1 mg

Brand:
Cayman
CAS:
189894-79-9
Storage:
-20
UN-No:
Non-Hazardous - /

C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{38646},{2814} C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM).{38647} It is metabolically inactive and, unlike C6 L-erythro ceramide (Item No. 24388), C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase.{40661} C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM. It enhances IL-4 production induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in EL4 T cells when used at a concentration of 10 μM.{13011} [Matreya, LLC. Catalog No. 1809]  

 

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SKU: 24389 - 1 mg Category:

Description

A cell-permeable analog of naturally occurring ceramides; cytotoxic to U937 cells in vitro (IC50 = 18 μM); metabolically inactive; promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater than 5 μM; enhances PMA-induced IL-4 production in EL4 T cells,

Formal name: N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexanamide

Synonyms:  D-threo Cer(d18:1/6:0)|D-threo Ceramide (d18:1/6:0)|N-hexanoyl-D-threo-Sphingosine

Molecular weight: 397.6

CAS: 189894-79-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience

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