C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide

C6 Ceramide (d18:1/6:0) – 25 mg

Brand:
Cayman
CAS:
124753-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides.{2756} C6 ceramide mediates many diverse biological activities including apoptosis,{3988} activation of protein phosphatase 2A,{2756,2757} and inhibition of the mitochondrial respiratory chain.{5031} It also enhances the expression of COX-2 in rat granulosa cells{5473} and stimulates the growth of bovine aortic smooth muscle cells.{3512} C6 ceramide acts in neuronal axons to inhibit neurite growth.{5302}  

 

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Description

C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides.{2756} C6 ceramide mediates many diverse biological activities including apoptosis,{3988} activation of protein phosphatase 2A,{2756,2757} and inhibition of the mitochondrial respiratory chain.{5031} It also enhances the expression of COX-2 in rat granulosa cells{5473} and stimulates the growth of bovine aortic smooth muscle cells.{3512} C6 ceramide acts in neuronal axons to inhibit neurite growth.{5302}

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexanamide

Synonyms:  ​C6 Ceramide|Cer(18:1/6:0)|Ceramide (d18:1/6:0)|N-Caproyl-C18-sphingosine|N-hexanoyl-D-erythro-sphingosine

Molecular weight: 397.6

CAS: 124753-97-5

Purity: ≥98%

Formulation: A crystalline solid

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