An activator of K2P2.1/TREK1 and K2P10.1/TREK2; increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM

C3001a – 10 mg

Brand:
Cayman
CAS:
2415154-29-7
Storage:
-20
UN-No:
- /

C3001a is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2.{59302} It increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels). C3001a is selective for K2P2.1/TREK1 and K2P10.1/TREK2 over a panel of five additional K2P channels at 10 µM. In vivo, C3001a (10 mg/kg) reduces edema and pancreatic necrosis in a mouse model of acute pancreatitis. It reduces mechanical and thermal hyperalgesia in a mouse model of chronic inflammatory pain induced by complete Freund’s adjuvant (CFA). C3001a (5 mg/kg) also reduces cold hyperalgesia in a mouse model of neuropathic pain induced by spared nerve injury (SNI).  

 

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SKU: 31064 - 10 mg Category:

Description

An activator of K2P2.1/TREK1 and K2P10.1/TREK2; increases current amplitude in HEK293T cells expressing K2P2.1/TREK1 or K2P10.1/TREK2 (EC50s = 12.81 and 11.31 µM, respectively, for the human channels); reduces edema and pancreatic necrosis in a mouse model of acute pancreatitis; analgesic in various mouse pain models

Formal name: (1S,3R)-3-[[[4-(6-methyl-2-benzothiazolyl)phenyl]amino]carbonyl]-cyclopentanecarboxylic acid

Synonyms: 

Molecular weight: 380.5

CAS: 2415154-29-7

Purity: ≥98%

Formulation: A crystalline solid

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