A naturally occurring sphingolipid; inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 19 μg/ml)

C24 (2’(R)-hydroxy) Phytoceramide (t18:0/24:0) – 1 mg

Brand:
Cayman
CAS:
154801-30-6
Storage:
-20
UN-No:
Non-Hazardous - /

C24 (2’(R)-hydroxy) Phytoceramide is a naturally occurring sphingolipid that has been found in adlay seed hull.{48601} It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and inducible nitric oxide synthase (iNOS) levels. It increases production of chemokine (C-X-C motif) ligand 8 (CXCL8), CXCL1, chemokine (C-C motif) ligand 2 (CCL2), and CCL20 in human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.{48602} C24 (2’(R)-hydroxy) Phytoceramide is a hydroxylated form of C24 phytoceramide (Item No. 22827). [Matreya, LLC. Catalog No. 2094]  

 

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Description

A naturally occurring sphingolipid; inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and iNOS levels; increases production of CXCL8, CXCL1, CCL2, and CCL20 in HUVECs in a concentration-dependent manner; a hydroxylated form of C24 phytoceramide

Formal name: (2R)-N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-2-hydroxy-tetracosanamide

Synonyms:  2′-(R)-hydroxy-C24 Phytoceramide|C24(2’OH)Phy|N-(R)-alpha-Hydroxytetracosanoyl-Phytosphingosine|N-(R)-α-C24 Phytosphingosine (t18:0/24:0)|N-24:0(2R-OH) Phytosphingosine

Molecular weight: 684.1

CAS: 154801-30-6

Purity: ≥98%

Formulation: A solid

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