A bioactive sphingolipid; forms small channels in liposomes

C22 Ceramide (d18:1/22:0) – 10 mg

Brand:
Cayman
CAS:
27888-44-4
Storage:
-20
UN-No:
Non-Hazardous - /

C-22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.{37099} C-22 ceramide forms small channels in liposomes, whereas C-16 ceramide (Item No. 10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C-22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.{37098}  

 

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Description

A bioactive sphingolipid; forms small channels in liposomes, suggesting that acyl chain length is important in mitochondrial-mediated apoptosis; decreases the mitochondrial-to-cytosolic stress response in C. elegans following hsp-6 RNAi

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-docosanamide

Synonyms:  C22 Ceramide|Cer(d18:1/22:0)|Ceramide (d18:1/22:0)

Molecular weight: 622.1

CAS: 27888-44-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Lipid Biochemistry|Sphingolipids

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