An internal standard for the quantification of C18 ceramide by GC- or LC-MS

C18 Ceramide-d7 (d18:1-d7/18:0) – 1 mg

Brand:
Cayman
CAS:
1840942-14-4
Storage:
-20
UN-No:
Non-Hazardous - /

C18 Ceramide-d7 is intended for use as an internal standard for the quantification of C18 ceramide (Item No. 19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.{40029} Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.{13918} It is selectively down-regulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.{40030}  

 

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Description

An internal standard for the quantification of C18 ceramide by GC- or LC-MS

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-15,15,16,16,17,17,17-d7]-octadecanamide

Synonyms:  C18 Ceramide-d7|Ceramide-d7 (d18:1-d7/18:0)|Cer-d7 (d18:1-d7/18:0)|N-Stearoyl-D-Sphingosine-d7

Molecular weight: 573

CAS: 1840942-14-4

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Lipid Biochemistry|Sphingolipids

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