A precursor in the de novo synthesis of C16 ceramide; inhibits C16 ceramide-induced membrane permeabilization in rat liver mitochondria and channel formation in liposomes; biologically inactive as a single agent

C16 dihydro Ceramide (d18:0/16:0) – 10 mg

Brand:
Cayman
CAS:
5966-29-0
Storage:
-20
UN-No:
Non-Hazardous - /

C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Item No. 10681) that lacks the 4,5-trans double bond.{41404} C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome C release, or channel formation in phospholipid membranes in the absence of C16 ceramide. [Matreya, LLC. Catalog No. 2078]  

 

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SKU: 24369 - 10 mg Category:

Description

A precursor in the de novo synthesis of C16 ceramide; inhibits C16 ceramide-induced membrane permeabilization in rat liver mitochondria and channel formation in liposomes; biologically inactive as a single agent

Formal name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-hexadecanamide

Synonyms:  Cer(d18:0/16:0)|Ceramide (d18:0/16:0)|N-hexadecanoyl-D-erythro-Dihydrosphingosine|N-Palmitoyl Sphinganine

Molecular weight: 539.9

CAS: 5966-29-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Lipid Biochemistry|Sphingolipids

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