A bioactive sphingolipid; levels increase time-dependently in a nutrient deprivation-induced necroptosis model in MEF cells; reduced levels in obese patients after chronic exercise correlate with weight and fat loss; higher levels in Parkinson’s disease patients correlate with memory deficits

C14 Ceramide (d18:1/14:0) – 10 mg

Brand:
Cayman
CAS:
34227-72-0
Storage:
-20
UN-No:
Non-Hazardous - /

C14 Ceramide is an endogenous ceramide generated by ceramide synthase 6.{35051} During nutrient-deprivation-induced necroptosis in MEF cells, C14 ceramide levels increase in a time-dependent manner.{35053} C14 ceramide plasma levels were reduced in obese patients with or without diabetes following a 12-week supervised exercise training program, correlating positively with weight and fat loss and negatively with an increase in insulin sensitivity.{35052} In contrast, plasma levels were higher in Parkinson’s disease patients with dementia than those without dementia and higher levels were correlated with deficits in memory.{35054}  

 

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Description

A bioactive sphingolipid; levels increase time-dependently in a nutrient deprivation-induced necroptosis model in MEF cells; reduced levels in obese patients after chronic exercise correlate with weight and fat loss; higher levels in Parkinson’s disease patients correlate with memory deficits,

Formal name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-tetradecanamide

Synonyms:  C14 Ceramide|Cer(d18:1/14:0)|Ceramide (d18:1/14:0)

Molecular weight: 509.9

CAS: 34227-72-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Cell Biology|Cell Death|Necroptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Lipid Biochemistry|Sphingolipids||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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