CRP is a 224 amino acid protein that is synthesized primarily by hepatocytes

C-Reactive Protein (human) ELISA Kit – 96 wells

Brand:
Cayman
Storage:
4

C-Reactive Protein (CRP) is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions.{15269} Normal levels of serum CRP (0.64 µg/ml) do not differ between healthy adult men and women, but tend to increase slightly with age.{15308} High plasma CRP concentrations (>3 µg/ml) are associated with an increased risk for atherosclerosis.{15307} CRP has been implicated as a contributor to atherogenesis by modulating endothelial function, stimulating coagulation, inducing the expression of ICAM-1, VCAM-1, and E-selectin, mediating uptake of LDL into macrophages, and destabilizing plaques.{15269,15777,15778,15779,10506,15280,15270} In addition, CRP can bind in a calcium-dependent manner to phosphocholine on microbes, act as a ligand for specific receptors on phagocytic leukocytes, mediate activation of monocytes and macrophages via IL-6, TNF-α and other cytokines, and assist in the complement pathway.{15269,15774,15775,15773} Cayman’s CRP (human) ELISA Kit is an immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 46.9-3,000 pg/ml with a limit of detection of approximately 46.9 pg/ml.  

 

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SKU: 10011236 - 96 wells Category:

Description

CRP is a 224 amino acid protein that is synthesized primarily by hepatocytes, and to a lesser extent adipocytes. CRP plasma levels increase ~1,000-fold in response to acute and chronic inflammatory conditions, making it a useful gauge of inflammation in a wide range of physiological and pathological conditions. High plasma CRP concentrations (>3 µg/ml) are associated with an increased risk for atherosclerosis. Cayman’s CRP (human) ELISA is a sensitive immunometric assay which can be used to measure CRP in plasma without prior sample purification. The standard curve spans the range of 46.9-3,000 pg/ml with a limit of detection of approximately 46.9 pg/ml.

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Synonyms:  CRP (human) EIA Kit

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Application|ELISA||Product Type|Assay Kits|ELISA||Research Area|Cardiovascular System|Blood|Acute Phase Reactants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis

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