A selective iNOS inhibitor (IC50s = 0.086

BYK 191023 (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
1216722-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

BYK 191023 is an L-arginine competitive and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 values of 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively.{36602} It also inhibits murine recombinant iNOS (IC50 = 95 nM). BYK 191023 inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively). In vivo, BYK 191023 suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour).{16676} It prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia when administered at a dose of 50 μmol/kg per hour. BYK 191023 also increases mean arterial pressure and renal blood flow in a sheep model of septic shock.{36603}  

 

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Description

A selective iNOS inhibitor (IC50s = 0.086, 17, and 162 μM for human recombinant iNOS, nNOS, and eNOS, respectively); inhibits iNOS-induced nitrite generation in RMC, RAW, and HEK293 cells (IC50s = 33, 3.1, and 13 μM, respectively); suppresses LPS-induced increases in plasma nitrate and nitrite levels in rats (ED50 = 14.9 μmol/kg per hour); prevents development of delayed hypotension in a rat model of LPS-induced endotoxemia at 50 μmol/kg per hour; increases mean arterial pressure and renal blood flow in a sheep model of septic shock

Formal name: 2-[2-(4-methoxy-2-pyridinyl)ethyl]-3H-imidazo[4,5-b]pyridine, dihydrochloride

Synonyms: 

Molecular weight: 327.2

CAS: 1216722-25-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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