BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.{1198

BW A868C – 1 mg

Brand:
Cayman
CAS:
118675-50-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.{1198,3328} BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.{3804} It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.{1254}  

 

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SKU: 12060 - 1 mg Category:

Description

BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.{1198,3328} BW A868C antagonizes the PGD2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.{3804} It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.{1254}

Formal name: 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid

Synonyms: 

Molecular weight: 459.6

CAS: 118675-50-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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