An 11β-HSD inhibitor; inhibits 11β-HSD1 activity in isolated liver and decreases blood glucose and insulin concentrations in a mouse model of hyperglycemia and hyperinsulinemia at 100 mg/kg; decreases the expression of MCP-1 and TNF-α in adipose tissue and reduces body weight and improves glucose tolerance and insulin sensitivity in a mouse model of high-fat diet-induced obesity; decreases TNF-α

BVT 2733 – 5 mg

Brand:
Cayman
CAS:
376640-41-4
Storage:
-20
UN-No:
Non-Hazardous - /

BVT 2733 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; Item No. 10007815).{36817} In a mouse model of hyperglycemia and hyperinsulinemia, BVT 2733 (100 mg/kg) inhibits 11β-HSD1 activity in isolated liver and decreases blood glucose and insulin concentrations. It decreases the expression of monocyte chemoattractant protein 1 (MCP-1) and TNF-α in adipose tissue, but not plasma, of mice with high-fat diet-induced obesity and normalizes the expression of adipokines in adipose tissue.{36818} It also reduces body weight and improves glucose tolerance and insulin sensitivity in high-fat diet-induced obese mice. BVT 2733 decreases TNF-α, IL-1β, IL-6, and IL-17 protein levels in serum and reduces severity of collagen-induced arthritis in mice.{36819}  

 

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Description

An 11β-HSD inhibitor; inhibits 11β-HSD1 activity in isolated liver and decreases blood glucose and insulin concentrations in a mouse model of hyperglycemia and hyperinsulinemia at 100 mg/kg; decreases the expression of MCP-1 and TNF-α in adipose tissue and reduces body weight and improves glucose tolerance and insulin sensitivity in a mouse model of high-fat diet-induced obesity; decreases TNF-α, IL-1β, IL-6, and IL-17 protein levels in serum and reduces severity of collagen-induced arthritis in mice

Formal name: 3-chloro-2-methyl-N-[4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-thiazolyl]-benzenesulfonamide

Synonyms: 

Molecular weight: 429

CAS: 376640-41-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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