A potent inhibitor of CCK-inactivating peptidase/TPP-2 (Ki = 7 nM); selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM); increases levels of CCK octapeptide in depolarized rat cerebral cortex slices; inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg

Butabindide (oxalate) – 10 mg

Brand:
Cayman
CAS:
185213-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

Butabindide is a potent inhibitor of cholecystokinin-inactivating peptidase/tripeptidyl peptidase 2 (CCK-inactivating peptidase/TPP-2; Ki = 7 nM).{37571} It is selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM). Butabindide (0.1-100 μM) increases levels of CCK octapeptide (Item Nos. 24404 | 23371) in depolarized rat cerebral cortex slices. In vivo, butabindide inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg, respectively). It also enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice.  

 

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Description

A potent inhibitor of CCK-inactivating peptidase/TPP-2 (Ki = 7 nM); selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM); increases levels of CCK octapeptide in depolarized rat cerebral cortex slices; inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg, respectively); enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice

Formal name: [S-(R*,R*)]-1-(2-amino-1-oxobutyl)-N-butyl-2,3-dihydro-1H-indole-2-carboxamide, monoethanedioate

Synonyms: 

Molecular weight: 393.4

CAS: 185213-03-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area

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