A non-specific β-adrenergic blocker with affinity for both β1 and β2-adrenergic receptors; acts as a potent β-adrenoceptor antagonist with partial agonist activity; metabolized by CYP2D6

Bufuralol (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
60398-91-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bufuralol is a non-specific β-adrenergic blocker with affinity for both β1 and β2-adrenergic receptors. It acts as a potent β-adrenoceptor antagonist with partial agonist activity.{29043} It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1’-hydroxylation.{29042}  

 

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Description

A non-specific β-adrenergic blocker with affinity for both β1 and β2-adrenergic receptors; acts as a potent β-adrenoceptor antagonist with partial agonist activity; metabolized by CYP2D6, CYP1A2, and CYP2C19

Formal name: α-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol, monohydrochloride

Synonyms:  Ro 3-4787

Molecular weight: 297.8

CAS: 60398-91-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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