A biguanide that exhibits antihyperglycemic activity by increasing glucose utilization and inhibiting hepatic gluconeogenesis; inhibits the mitochondrial respiratory complex I and the mitochondrial ATP synthase; disrupts the unfolded protein response transcription program during glucose deprivation

Buformin (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
1190-53-0
Storage:
-20
UN-No:
Non-Hazardous - /

Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis.{29950} It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis.{29952} Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin.{29949} Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase.{29949} Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.{29951}  

 

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Description

A biguanide that exhibits antihyperglycemic activity by increasing glucose utilization and inhibiting hepatic gluconeogenesis; inhibits the mitochondrial respiratory complex I and the mitochondrial ATP synthase; disrupts the unfolded protein response transcription program during glucose deprivation, inducing cell death in glucose-deprived tumor cells

Formal name: N-butyl-imidodicarbonimidic diamide, monohydrochloride

Synonyms:  N-butyl Biguanide

Molecular weight: 193.7

CAS: 1190-53-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Metabolism||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|ER Protein Folding||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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