A glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay); selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7

Budesonide – 50 mg

Brand:
Cayman
CAS:
51333-22-3
Storage:
-20
UN-No:
Non-Hazardous - /

Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay).{41565} It is selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM). Budesonide inhibits LPS-induced TNF-α release from human peripheral blood mononuclear cells (PBMCs; IC50 = 0.96 nM).{25238} It reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a rat model of ovalbumin-induced airway inflammation when administered at a dose of 3 mg/kg.{24240} Intracolonic administration of budesonide decreases colon wet weight and colonic myeloperoxidase (MPO) activity in a rat model of oxazolone-induced colitis.{52378} Formulations containing budesonide have been used in the treatment of Crohn’s disease, ulcerative colitis, allergic rhinitis, and asthma.  

 

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Description

A glucocorticoid and an agonist of glucocorticoid receptors (EC50 = 45.7 pM in a transactivation assay); selective for glucocorticoid over mineralocorticoid receptors (EC50 = 7,620 pM); inhibits LPS-induced TNF-α release from human PBMCs (IC500 = 0.96 nM); reduces levels of IL-1β and eotaxin in the lungs and the number of eosinophils and neutrophils in BALF in a rat model of ovalbumin-induced airway inflammation at 3 mg/kg; intracolonic administration decreases colon wet weight and colonic MPO activity in a rat model of oxazolone-induced colitis

Formal name: 16α,17-[butylidenebis(oxy)]-11β,21-dihydroxy-pregna-1,4-diene-3,20-dione

Synonyms: 

Molecular weight: 430.5

CAS: 51333-22-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Gastric Disease|Crohn’s Disease||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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