An antihistamine; reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs at 1 mg/kg; induces gross malformations and bone malformations in rats from 40-200 mg/kg; inhibits cancer cell growth by binding to TCTP and inducing cell differentiation

Buclizine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
129-74-8
Storage:
-20
UN-No:
Non-Hazardous - /

Buclizine is an antihistamine.{36933} It reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs when administered at a dose of 1 mg/kg. Buclizine (40-200 mg/kg) induces gross malformations, including fusion of the tongue to the palate, cleft palate, micrognathia, and micromelia, and bone malformations in rats.{36934} It also inhibits cancer cell growth by binding to translationally controlled tumor protein (TCTP) and inducing cell differentiation.{36935} Formulations containing buclizine have been used to treat nausea induced by pregnancy and motion sickness.  

 

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SKU: 25641 - 1 g Category:

Description

An antihistamine; reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs at 1 mg/kg; induces gross malformations and bone malformations in rats from 40-200 mg/kg; inhibits cancer cell growth by binding to TCTP and inducing cell differentiation

Formal name: 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-piperazine, dihydrochloride

Synonyms:  NSC 25141

Molecular weight: 506

CAS: 129-74-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Cancer||Research Area|Immunology & Inflammation|Allergy||Research Area|Toxicology

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