A quassinoid with diverse biological activities; active against T. evansi (IC50 = 0.017 µg/ml); induces lipolysis in 3T3-L1 adipocytes at 160 nM; cytotoxic to HT-29

Bruceine A – 5 mg

Brand:
Cayman
CAS:
25514-31-2
Storage:
-20
UN-No:
Non-Hazardous - /

Bruceine A is a quassinoid that has been found in B. javanica and has diverse biological activities.{46882,46883,46884} It is active against T. evansi (IC50 = 0.017 µg/ml).{46882} Bruceine A induces lipolysis in 3T3-L1 adipocytes when used at a concentration of 160 nM.{46883} It is cytotoxic to HT-29, HeLa, and HL-60 cells (IC50s = 1.6, 0.6, and 0.069 µg/ml, respectively) and inhibits NF-κB activity in HeLa cell extracts (IC50 = 2.2 µg/ml).{46884}  

 

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Description

A quassinoid with diverse biological activities; active against T. evansi (IC50 = 0.017 µg/ml); induces lipolysis in 3T3-L1 adipocytes at 160 nM; cytotoxic to HT-29, HeLa, and HL-60 cells (IC50s = 1.6, 0.6, and 0.069 µg/ml, respectively); inhibits NF-κB activity in HeLa cell extracts (IC50 = 2.2 µg/ml)

Formal name: (11β,12α,15β)-13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-picras-3-en-21-oic acid, methyl ester

Synonyms:  Dihydrobrusatol|NSC 310616

Molecular weight: 522.5

CAS: 25514-31-2

Purity: ≥98%

Formulation: A solid

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