An immunomodulator with diverse biological activities; a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs; dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week; reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg; delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE

Bropirimine – 25 mg

Brand:
Cayman
CAS:
56741-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

Bropirimine is an immunomodulator with diverse biological activities.{45710,45711,45712,45713} It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody.{45710} Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma.{45711} Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis.{45712} It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).{45713}  

 

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Description

An immunomodulator with diverse biological activities; a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs; dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week; reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg; delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE

Formal name: 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone

Synonyms:  ABPP|NSC 149027|PNU 54461|U-54461

Molecular weight: 266.1

CAS: 56741-95-8

Purity: ≥95%

Formulation: A crystalline solid

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