A D2 receptor antagonist (Ki = 14 nM) with prokinetic and antiemetic properties; binds to bovine anterior pituitary membranes (IC50 = 2.13 μM); inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM

Bromopride – 1 mg

Brand:
Cayman
CAS:
4093-35-0
Storage:
-20
UN-No:
Non-Hazardous - /

Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM).{46566} It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM.{46567} Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively).{46568} It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg.{46567} Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.{46569}  

 

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Description

A D2 receptor antagonist (Ki = 14 nM) with prokinetic and antiemetic properties; binds to bovine anterior pituitary membranes (IC50 = 2.13 μM); inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively); increases serum prolactin levels in rats (ED200 = 0.02 mol/kg); decreases locomotion and rearing in an open field test and impairs acquistion of a conditioned avoidance response in a two-way active conditioned avoidance test in rats

Formal name: 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide

Synonyms:  Emepride|Emoril|Viadil

Molecular weight: 344.3

CAS: 4093-35-0

Purity: ≥95%

Formulation: A solid

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