A COX-2 inhibitor (IC50 = 6.6 nM); selective over COX-1 (IC50 = 210 nM); inhibits PGE2 production in a rabbit model of LPS-induced eye inflammation; decreases inflammation following cataract removal in dogs (0.9% topically on a tapering schedule for 24 weeks)

Bromfenac (sodium salt) – 50 mg

Brand:
Cayman
CAS:
91714-93-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM).{39441} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.{39440} Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.  

 

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SKU: 23763 - 50 mg Category:

Description

A COX-2 inhibitor (IC50 = 6.6 nM); selective over COX-1 (IC50 = 210 nM); inhibits PGE2 production in a rabbit model of LPS-induced eye inflammation; decreases inflammation following cataract removal in dogs (0.9% topically on a tapering schedule for 24 weeks)

Formal name: 2-amino-3-(4-bromobenzoyl)-benzeneacetic acid, monosodium salt

Synonyms:  AHR 10282B

Molecular weight: 356.2

CAS: 91714-93-1

Purity: ≥99%

Formulation: A powder

Application||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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