A second generation anticoagulant rodenticide; an inhibitor of VKOR that inhibits blood clotting; inhibits human VKORC1 (IC50 = 1.6 nM); toxic to rodents

Bromadiolone – 100 mg

Brand:
Cayman
CAS:
28772-56-7
Storage:
-20
UN-No:
- 2811 / 6.1

Bromadiolone is a second generation anticoagulant rodenticide and 4-hydroxycoumarin derivative.{45454,45455} It is an inhibitor of vitamin K epoxide reductase (VKOR) that inhibits blood clotting. It inhibits human VKOR complex subunit 1 (VKORC1) with an IC50 value of 1.6 nM in a cell-based assay.{45456} Bromadiolone is toxic to rodents, including mice (LD50 = 1.75 mg/kg) and rats (LD50s = 1.05 and 1.83 mg/kg for males and females, respectively).{45461,45462} It does not significantly affect breeding performance in mice when administered at a dose of up to 70% of the LD50 value.{45463} Resistance to bromadiolone is conferred by mutations to the VKOR gene, Vkorc1.{45464} Formulations containing bromadiolone have been used in the control of rodent pest populations.  

 

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Description

A second generation anticoagulant rodenticide; an inhibitor of VKOR that inhibits blood clotting; inhibits human VKORC1 (IC50 = 1.6 nM); toxic to rodents, including mice (LD50 = 1.75 mg/kg) and rats (LD50s = 1.05 and 1.83 mg/kg for males and females, respectively); does not significantly affect breeding performance in mice at 70% of the LD50 value

Formal name: 3-[3-(4′-bromo[1,1′-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one

Synonyms:  Bromatrol|Broprodifacoum

Molecular weight: 527.4

CAS: 28772-56-7

Purity: ≥95% (mixture of diastereomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Toxicology|Environmental

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