A 5-HT1D receptor antagonist (Ki = 0.013 µM in CHO cell membranes expressing the human receptor); selective for 5-HT1D over several other G protein-coupled 5-HT receptor subtypes (Kis = 0.25-6.3 µM) but does bind 5-HT1A and 5-HT2B receptors (Kis = 0.02 and 0.04 µM

BRL 15572 – 10 mg

Brand:
Cayman
CAS:
193611-72-2
Storage:
-20
UN-No:
Non-Hazardous - /

BRL 15572 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 0.013 µM in CHO cell membranes expressing the human receptor).{54405} It is selective for 5-HT1D over several other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 0.25 to 6.3 µM but does bind 5-HT1A and 5-HT2B receptors (Kis = 0.02 and 0.04 µM, respectively). BRL 15572 also acts as a partial agonist at 5-HT1D receptors (EC50 = 0.008 µM in a [35S]GTPγS binding assay).  

 

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SKU: 31191 - 10 mg Category:

Description

A 5-HT1D receptor antagonist (Ki = 0.013 µM in CHO cell membranes expressing the human receptor); selective for 5-HT1D over several other G protein-coupled 5-HT receptor subtypes (Kis = 0.25-6.3 µM) but does bind 5-HT1A and 5-HT2B receptors (Kis = 0.02 and 0.04 µM, respectively; also acts as a partial agonist at 5-HT1D receptors (EC50 = 0.008 µM in a [35S]GTPγS binding assay)

Formal name: 4-(3-chlorophenyl)-α-(diphenymethyl)-1-piperazineethanol, dihydrochloride

Synonyms: 

Molecular weight: 479.9

CAS: 193611-72-2

Purity: ≥98%

Formulation: A solid

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