A neurotoxin that binds to voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction

Brevetoxin B – 100 µg

Brand:
Cayman
CAS:
79580-28-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.{31511,31512} Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.{31512}  

 

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SKU: 10011498 - 100 µg Category:

Description

A neurotoxin that binds to voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively; ichthyotoxic at nanomolar concentrations

Formal name: brevetoxin B

Synonyms:  Brevetoxin 2|BTX-B|GbTx-2|PbTx-2

Molecular weight: 895.1

CAS: 79580-28-2

Purity: ≥95%

Formulation: A film

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Toxins||Research Area|Neuroscience||Research Area|Toxicology|Environmental|Aquatic Systems

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